Document Details
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Document Type |
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Article In Journal |
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Document Title |
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Estimation of Interleukin‐1β Promoter (− 31 C/T and− 511 T/C) Polymorphisms and Its Level in Coronary Artery Disease Patients Estimation of Interleukin‐1β Promoter (− 31 C/T and− 511 T/C) Polymorphisms and Its Level in Coronary Artery Disease Patients |
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Document Language |
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Arabic |
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Abstract |
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Interleukin-1b (IL-1b) is an inflammation-causing cytokine that exerts several unique biological effects and could lead to future adverse
events of CAD. The piece of work presented herein is aimed at investigating possible association of IL-1b levels to its polymorphic site
viz. 511 and 31 at promoter region in Saudi CAD patients. The study included 155 confirmed CAD patients and 80 healthy control
individuals both men and women. Concentration of IL-1b in the patients’ serum was measured by ELISA method. For single nucleotide
polymorphism (SNP) analysis, sanger method of DNA sequencing was followed. We observed variable numbers of SNPs at 31 C/T and 511
T/C promoter regions in Saudi patients suffering from CAD in comparison to the control set of individuals. However, the changes in the number
of SNP-hotspots were determined to be non-significant with reference to the control set. The haplotype analysis at 31 and 511 also did not
show any significant changes between control and CAD patients. Moreover, serum IL-1b levels were observed to be expressively higher in
patients suffering from CAD (P<0.001) and its associated complications viz. STEMI (P<0.001), NSTEMI (P<0.001), and UA (P<0.001). Our
study provides the status of SNPs at IL-1b promoter in Saudi population. As per our information, ours is the first article that shows the genetic
diversity in IL-1b promoters and its level in the Saudi CAD patients. J. Cell. Biochem. 9999: 1–6, 2017. © 2017 Wiley Periodicals, Inc. |
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ISSN |
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1097-4644 |
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Journal Name |
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Journal of Cellular Biochemistry |
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Volume |
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1 |
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Issue Number |
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1 |
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Publishing Year |
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1438 AH
2017 AD |
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Article Type |
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Article |
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Added Date |
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Tuesday, May 16, 2017 |
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Researchers
| Shams Tabrez | Tabrez, Shams | Investigator | Doctorate | |
| Nasimudeen R Jabir | Jabir, Nasimudeen R | Researcher | Doctorate | |
| Chelapram K Firoz | Firoz, Chelapram K | Researcher | Doctorate | |
| Salwa Hindawi | Hindawi, Salwa | Researcher | Doctorate | |
| Shazi Shakil | Shakil, Shazi | Researcher | Doctorate | |
| Ghazi A Damanhouri | Damanhouri, Ghazi A | Researcher | Doctorate | |
| Syed Kashif Zaidi | Zaidi, Syed Kashif | Researcher | Doctorate | |
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